000			04518cam a22004098i 4500
001			on1226072838
003			OCoLC
005			20211020083519.0
008			201202s2021 nyu e b 001 0 eng
010			_a 2020054280
040			_aDNLM/DLC _beng _erda _cDLC _dOCLCO _dBDX _dYDX _dOCLCA _dFNN _dOCLCO _dON8 _dJAO _dRNL _dUOK _dOCLCF _dNFG
020			_a9781541620391 _q(hardcover)
020			_a1541620399 _q(hardcover)
035			_a(OCoLC)1226072838
042			_apcc
092			_a615.58 _bO32
049			_aNFGA
100	1		_aOffit, Paul A., _eauthor. _9145610
245	1	0	_aYou bet your life : _bfrom blood transfusions to mass vaccination, the long and risky history of medical innovation / _cPaul A. Offit, MD.
250			_aFirst edition.
264		1	_aNew York : _bBasic Books, _c2021.
264		4	_c©2021
300			_a258 pages ; _c25 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references (pages 223-240) and index.
505	0		_aLouis Washkansky : heart transplants -- Ryan White : blood transfusions -- Hannah Greener : anesthesia -- "Jim" : biologicals -- Joan Marlar : antibiotics -- Anne Gottsdanker : vaccines -- Clarence Dally : x-rays -- "Eleven unnamed children" : chemotherapy -- Jesse Gelsinger : gene therapy -- Epilogue : living with uncertainty.
520			_a"Four months into the coronavirus pandemic, as the death count surged, the FDA made a risky decision: it approved an anti-malarial drug as a treatment for coronavirus, despite limited data on its efficacy or side effects. A month later, the FDA withdrew its recommendation, but by then, the damage had been done. The drug was ineffective and sometimes even lethal. The mistake was hardly a one-off. As virologist Paul. A. Offit shows in You Bet Your Life, from antibiotics and vaccines to x-rays and genetic engineering, risk, and our understanding of it, have shaped the course of modern medicine, paving the way for its greatest triumphs and tragedies. By telling the stories of the events--and of the frequent hypocrisy and cravenness of the characters at their center--Offit shows how risk, and failure, have driven innovation, and importantly, how by examining our mistakes we can make better medical predictions and decisions going forward. From the outlandish origins of blood transfusions, which began with humans receiving blood for barnyard animals, to the disastrous debut of the first polio vaccine, and the backstabbing and infighting that surrounded early gene therapies, he captures the drama that surrounds medical research, the way ego and laziness can collide with science, and ultimately how those factors should inform what we choose to do and have done to us in the clinic. The history is fascinating in its own right, but the worldwide rush to create a coronavirus vaccine only makes learning from the lessons of history essential. Weighing the uncertainties of a treatment against its potential benefits is one of medicine's greatest ethical dilemmas, and Offit examines it from every angle. He explores not just how patients and their families respond to risk but how everyone from physicians and researchers to universities and regulators do, too, and how that ultimately determines what treatments are put forward. Not everyone has the same goal. And too often the patient's health is secondary. But as Offit shows, we can all minimize risk and failure by learning how to recognize conflicts of interest, to draw inferences from animal models, and to evaluate risk, even when we have limited data. Along the way, Offit asks who should decide what risks are acceptable, and who should pay when the results are fatal. In the end, however, Offit argues that we are gambling whatever we do--and that we need to take that seriously, whether we pursue a treatment or decide to do nothing at all. The answers aren't simple, and the outcomes are life or death. Examining these questions with the compassion of a pediatrician and the rigor of a scientist, Offit reminds us that we all have a role to play in ensuring that medicine upholds its very first principle: to do no harm"-- _cProvided by publisher.
650		0	_aTherapeutics _xHistory.
650		0	_aTherapeutics _xComplications.
650		0	_aDiffusion of innovations. _990449
650		0	_aMedicine _xResearch _xHistory. _9104640
650		0	_aBiotechnology _xRisk assessment.
650		0	_aBioethics. _9230086
994			_aC0 _bNFG
999			_c334791 _d334791