000			03471cam a2200349 i 4500
001			on1398568560
003			OCoLC
005			20240613143854.0
008			230923t20242024nyua b 001 0 eng d
040			_aYDX _beng _erda _cYDX _dLIV _dLMJ _dY$5 _dPX0 _dOCO _dOCLCO _dIUK _dIMT _dXTZ _dJQM _dOCLCO _dNFG
020			_a9781324050681 _q(hardcover)
020			_a1324050683 _q(hardcover)
035			_a(OCoLC)1398568560
092			_a572.88 _bC387
049			_aNFGA
100	1		_aCech, Thomas, _eauthor.
245	1	4	_aThe catalyst : _bRNA and the quest to unlock life's deepest secrets / _cThomas R. Cech.
250			_aFirst edition.
264		1	_aNew York, NY : _bW. W. Norton & Company, _c[2024]
264		4	_c©2024
300			_a292 pages : _billustrations ; _c24 cm
334			_asingle unit _2rdami
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references (pages 251-280) and index.
505	0		_aIntroduction: The age of RNA -- Part I: The search. The messenger -- Splice of life -- Going it alone -- The shape of a shapeshifter -- The mothership -- Origins -- Part II: The cure. Is the fountain of youth a death trap? -- As the worm turns -- Precise parasites, sloppy copies -- RNA versus RNA -- Running with scissors -- Epilogue: The future of RNA.
520			_a"One of Literary Hub's Most Anticipated Books of 2024. Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize-winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA--long overlooked as the passive servant of DNA--sits at the center of biology's greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century. A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA--once thought merely to transmit DNA's genetic instructions to the cell's protein-making machinery--may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies--from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more--may enable us to improve and even extend life beyond nature's current limits. Written by one of our foremost scientists, The Catalyst is a must-read guide to the present and future of biology and medicine"-- _cProvided by publisher.
650		0	_aRNA.
650		0	_aGenomics. _9235948
994			_aC0 _bNFG
999			_c383192 _d383192